Antihypertensive effect of hypophysectomy in dogs with hypertension following bilateral carotid sinus constriction.

A chronic type of experimental hypertension has been produced in dogs by bilateral sinus area constriction. Hypophysectomy has a prolonged antihypertensive effect in dogs with persistent hypertension resulting from carotid sinus area constriction, while no decrease in mean arterial pressure is seen after hypophysectomy in normotensive control dogs. These findings suggest the possibility that altered hypophyseal function participates in the pathogenesis of this typ^ of hypertension.